Ali-sman, Brain Tumors

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Medicina
Ali-sman, Brain Tumors

Ali-sman, Brain Tumors

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$24.900

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9781588290427

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1 KGS

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A comprehensive guide for both scientists and clinicians to recent advances in our understanding of the cellular and molecular processes involved in the initiation, progression, and clinical and biological behavior of brain tumors. The authors review the latest findings on the molecular biology, genetics, epidemiology, and pathology of brain tumors, detailing new knowledge about molecular profiling, molecular pathology and classification, in vitro and in vivo brain tumor models, brain metastasis, and progenitor cell biology. They also discuss in depth the cellular and genetic pathways involved in brain oncogenesis, malignant progression, and therapeutic response, highlighting oncogenes and tumor suppressor genes, DNA damage and repair, invasion and migration, cell cycle, growth factors, signaling, apoptosis, and developmental biology. The discussion of brain tumor therapy focuses on advances in pharmacological thinking, therapeutic modalities, novel therapeutic targets, rational drug design, gene and viral therapies, drug delivery and the blood brain barrier, immunotherapy, and brain imaging.

Part I: Epidemiology, Biology, Genetics, and Pathology
Epidemiology of Brain Tumors
Randa El-Zein, Melissa Bondy, and Margaret Wrensch
Molecular Genetics of Tumors of the Central Nervous System
C. David James
Molecular Pathology of Nervous System Tumors
Catherine L. Nutt, Anat O. Stemmer-Rachamimov, J. Gregory Cairncross, and David N. Louis
Genetic Modeling of Glioma Formation in Mice
Martin Begemann, Vinagolu K. Rajasekhar, Gregory N. Fuller, and Eric C. Holland
Biology of Brain Metastasis
Minsoo Kang, Takamitsu Fujimaki, Seiji Yano, and Isaiah J. Fidler
Analysis of Neural Precursor Cells in the Context of Origin of Brain Tumors, Their Treatment, and Repair of Treatment-Associated Damage
Mark Noble and Joerg Dietrich
Biology of Primitive Neuroectodermal Tumors
John R. Hill, Shoichiro Ohta, and Mark A. Israel
Part II: Mechanisms and Pathways
Molecular and Cellular Biology of the Blood-Brain Barrier and Its Characteristics in Brain Tumors
Helga E. de Vries, Lisette Montagne, Christine D. Dijkstra, and Paul van der Valk
Immune Regulation in the Brain: Lessons From Autoimmunity and Implications for Brain Tumor Therapy
Lois A. Lampson
Genetic Pathways in the Evolution of Gliomas
Hiroko Ohgaki and Paul Kleihues
DNA Damage and Repair in the Therapeutic Response of Tumors of the Central Nervous System
Henry S. Friedman, M. Eileen Dolan, and Francis Ali-Osman
Role of Urokinase-Type Plasminogen Activator Receptor in Human Glioma Invasion
Sanjeeva Mohanam and Jasti S. Rao
Regulation of Cell Cycle and Apoptosis in Human Brain Tumors
Juan Fueyo, Candelaria Gomez-Manzano, and Timothy J. McDonnell
Part III: Therapeutics
Systemic Chemotherapy for Metastatic Tumors of the Central Nervous System
Charles A. Conrad and W. K. Alfred Yung
Radiation Biology and Therapy of Tumors of the Central Nervous System
Nalin Gupta, John R. Fike, Penny K. Sneed, Philip J. Tofilon, and Dennis F. Deen
Advances in the Management of Cerebral Metastases
Fadi Hanbali and Raymond Sawaya
Immunotherapy of Central Nervous System Tumors: Contemporary Cancer Research
Amy B. Heimberger, David A. Reardon, Darell D. Bigner, and John H. Sampson
Targeting Drugs to Tumors of the Central Nervous System
Maciej S. Lesniak, James Frazier, and Henry Brem
Rational Design and Development of Targeted Brain Tumor Therapeutics
Francis Ali-Osman, Henry S. Friedman, Gamil R. Antoun, David Reardon, Darell D. Bigner, and John K. Buolamwini
Index